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This review explores the role of the SARS-CoV-2 spike protein in neurological disorders, both from natural infection and gene-based COVID-19 vaccines (anti-SARS-CoV-2 products, ASPs). The review focuses on how spike protein may cause neurological, vascular, inflammatory, and degenerative damage, especially in the central nervous system. This suggests that both SARS-CoV-2 infection and gene-based COVID-19 vaccines may cause similar neurological issues through shared spike protein-related mechanis