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Paul’s Academy of Medical Sciences on Instagram: "The specific inflammatory mediator primarily responsible for transforming macrophages into epithelioid cells is Interferon-gamma (IFN-\gamma). While several cytokines are involved in the broader granuloma formation, IFN-\gamma is the critical signal that drives the specific differentiation of a standard macrophage into the specialized “epithelioid” phenotype. Key Mediators Involved * Interferon-gamma (IFN-\gamma) [The Driver]: * Source: Secreted
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