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Herpes in Pregnancy Managing Herpes in Pregnancy Simplified! The mention of herpes in pregnancy can be alarming for both the patient and the clinician. Here's a quick, evidence-based guide to keep your practice up-to-date. 🤰 1. Acute Infection: If a pregnant patient develops a herpes lesion at any trimester, the drug of choice remains Acyclovir. 2. Prevention of Neonatal Herpes: This is the critical part! For any pregnant woman with a history of genital herpes, start prophylactic suppressive an