Maintaining mitochondrial DNA (mtDNA) integrity is crucial for cardiomyocyte function, and its disruption plays a significant role in ischemia/reperfusion (I/R) injury. This review sheds light on the ...

For years we’ve been told that MtDNA (maternal DNA) is passed from mother to children, both male and female, but only ...

The tiny little powerhouses of our cells, the mitochondria, are unique among organelles because they carry their own tiny ...

Hepatic cell carcinoma (HCC), the fifth most prevalent malignancy worldwide and the fourth leading cause of cancer-related mortality, poses significant therapeutic challenges. Despite advancements in ...

The AHA recommended whole exome or whole genome sequencing as first-line diagnostic tools for mitochondrial diseases.

According to a recent AHA Scientific Statement, despite ongoing limitations, recent advances in genomic sequencing ...

Geneticists looking inside the nuclear genome for mutations that contribute to disease have long relied on a principal known as constraint modeling, which allows researchers to assess the degree of ...

Almost every type of human cell is powered by mitochondria, bean-shaped organelles that use oxygen to synthesize usable energy.* These structures evolved billions of years ago from free-swimming ...

PD is a neurodegenerative movement disorder with progressive loss of dopaminergic neurons that causes tremors, rigidity, bradykinesia, and postural instability. High-throughput markers are needed to ...

Researchers identified a new, sticky form of mitochondrial DNA damage that builds up at dramatically higher levels than in nuclear DNA. These lesions disrupt energy production and activate ...