BRCA1 and BRCA2 are genes that help prevent tumors from growing. If you inherit a change, or mutation, in these genes, they stop doing their jobs, and cancer can develop. In the United States, about 1 ...

Sometimes the most stunning advances in science are based on a hunch that a dedicated investigator just can’t shake. That was the case with Mary-Claire King, professor of genome sciences and of ...

Ribbon structure of the BRCA2 protein. Mutations in the BRCA2 gene are linked to increased risk of breast cancer. New work from UC Davis shows how individual BRCA2 proteins work to repair damaged DNA, ...

Mutation of the breast cancer susceptibility gene, BRCA2, leads to breast and ovarian cancers. Mechanistic insight into the functions of human BRCA2 has been limited by the difficulty of isolating ...

The structural integrity of DNA is continually being challenged due to the presence of physical and chemical carcinogens in our environment. In addition to DNA lesions caused by exogenous agents, DNA ...

Prostate cancer is the leading cause of cancer and the second leading cause of cancer deaths in American men. Tumors often grow slowly and develop in individuals older than 65. But certain inherited ...

The initials BRCA2 may be best known for a gene associated with many cases of breast cancer, and the protein encoded by the BRCA2 gene is critical to repairing breaks in DNA. The breakdown of this ...

The past decade has witnessed a rapid expansion of genetic tests, including new instruments to inform patients who have been diagnosed with breast cancer about the risk of recurrence and to guide ...

What Is Akeega, and Why Does It Matter? Akeega is a dual-action tablet combining two medicines — niraparib and abiraterone acetate — that has been approved by the FDA in combination with prednisone (a ...

FDA approved niraparib, abiraterone acetate, and prednisone for BRCA2-mutated metastatic castration-sensitive prostate cancer, showing significant rPFS improvement in the AMPLITUDE trial. The ...

A team of clinician-scientists and scientists from the University of Nottingham (Malaysia campus), National Cancer Centre Singapore (NCCS), Cancer Research Malaysia, Nanyang Technological University, ...