Membrane proteins are key components of living cells. They constitute one-third of the ORFs of virtually all genomes, perform crucial roles, and are targeted by a huge number of drugs. When present in ...
In silico antibody accessibility analysis indicates that ectodomain epitopes are transiently exposed, while MPER epitopes are virtually always occluded in the pre-fusion trimer.
Numerous solutions have already been proposed to reduce the thickness gradient and potential for dry spots. In reference [2], the main existing solutions were presented and a multifunctional solution, ...
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