Lysine methylation is a pivotal post‐translational modification that modulates protein function by the addition of methyl groups to the ε‐amine of lysine residues. This modification, catalysed by ...

BACKGROUND: Aortic valve calcification increases leaflet stiffness and contributes to the development of calcific aortic valve disease. The molecular and cellular mechanisms underlying calcification ...

Cardiovascular disease remains the leading cause of mortality worldwide, necessitating deeper insights into its molecular underpinnings beyond genetic predisposition. Epigenetic modifications, ...

Elevated TRMT10C protein levels in Alzheimer's disease result in methylation of mitochondrial mRNA and subsequently in the suppression of the synthesis of a subunit protein of complex I of the ...

In genetics, one harmful variant can be enough to cause disease—but two can make it far more severe. One notable example is KJ, an infant diagnosed with a rare urea cycle disorder with a grim ...

This fully updated volume explores a wide array of new and state-of-the-art tools and resources for protein function prediction. Beginning with in-depth overviews of essential underlying computational ...