The tumor suppressor gene RASSF1 contributes to the spatiotemporal regulation of mitosis through a new mechanism. By interacting with Cdc20, its protein product RASSF1A inhibits the anaphase-promoting ...
During metaphase, chromosomes align and form bi-oriented attachments to spindle microtubules, leading to faithful chromosome segregation. Errors in kinetochore–microtubule attachment occur during ...
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