The chemical origin of life on Earth is a puzzle that scientists have been trying to piece together for decades. Many hypotheses have been proposed to explain how life came to be and what chemical and ...

Nucleic acid synthesis underpins life’s vital processes, from replication and transcription to the regulation of gene expression, while polymerase enzymology explores the molecular mechanisms by which ...

Nucleic acids are complex biological molecules that store and transmit genetic information in all living organisms. They are essential for the survival and reproduction of life on Earth. The two main ...

As a molecular biologist, I always enjoy reading articles concerning DNA and RNA. Your excellent article in the April 3, 2023, issue of C&EN (page 18) titled “The Promise of Peptide Nucleic Acids” ...

Metal-mediated base pairing in nucleic acids represents a transformative approach wherein traditional Watson–Crick hydrogen bonds are replaced or supplemented by coordinate bonds with metal ions. This ...

A recent perspective article published in the journal Nature Reviews Drug Discovery discussed the evolution of lipid nanoparticles (LNPs) for nucleic acid delivery. The authors, Pieter Cullis, ...

A recent Science paper discusses the utilization of a previously reported synthetic Escherichia coli to produce virus-resistant synthetic polymers for future drug production applications. By ...

DNA is the poster child for high-specificity binding. As long as their base sequences match, two complementary strands of DNA can navigate through a sea of biomolecules, find each other, and hold fast ...

The biosecurity risks associated with an unregulated industry became evident when, in 2006, a Guardian reporter successfully ordered parts of the smallpox genome through the mail. Although ordering ...