Figure 1: Structural insights into residues involved in modification-induced nucleosome stability. Figure 2: Potential effects of histone modifications on histone–DNA and histone–histone interactions.
Nucleosomes are the building blocks of chromatin and are composed of protein spools made from histone octamers, around which the DNA wraps in almost two turns. The nucleosomes form arrays, which are ...
DNA–protein cross-links (DPCs) represent a severe form of DNA damage that can disrupt essential chromatin-based processes. Among them, DNA–histone cross-links (DHCs) occur frequently within ...
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