Ever since loss-of-function variants in the gene for PILRA, short for paired immunoglobulin-like type 2 receptor alpha, turned up as protecting against Alzheimer’s disease, scientists have wondered ...

Using Alzheimer’s mouse models, human cells, and human brain tissue, the researchers demonstrated that lowering PU.1 promotes the expression of lymphoid immunoregulatory receptor proteins on microglia ...

A rare but potent genetic mutation that alters a protein in the brain’s immune cells, known as microglia, can give people as much as a three-fold greater risk of developing Alzheimer’s disease. A new ...

A collision happens. Someone is hurt, a head injury, a concussion. Just as the first responders arrive to help the person, inside the brain, another “crew” of responders is busy clearing debris and ...

The brain is a special organ, and immune cells there called microglia work to repair damage and maintain the health of neural networks. About ten percent of brain cells are estimated to be microglia, ...

In the search for answers about Alzheimer’s disease, researchers are taking a close look at the immune system of the brain. A new study uncovers how a key immune cell, called a microglia, might be the ...

Microglia, the primary immune cells in the brain, play vital roles in neurogenesis, homeostasis maintenance, synaptic plasticity, and brain development. They are widely used in monoculture for ...

The idea that infiltrating T cells contribute to a neurodegenerative environment in aging and in Alzheimer’s disease has gotten another boost. In the June 27 Nature Neuroscience, scientists led by ...