Interleukin-9 is a pleiotropic cytokine associated with allergic inflammation 1 and is a therapeutic target in patients with asthma. Its expression and that of the interleukin-9 receptor are greater ...

CI denotes confidence interval, and SNP single-nucleotide polymorphism. Sequencing reads were aligned to the hg19 reference genome. A SIFT (sorting intolerant from tolerant) score of less than 0.05 ...

Interleukin (IL)-1 is a prototypic proinflammatory cytokine. It is produced by numerous cell types (i.e., macrophages, synoviocytes, endothelial cells, chondrocytes, osteoclasts) and is found in ...

However, imbalances of IL-6 — too much or too little — can cause disease, even in the absence of infection. Excess IL-6 is central to the pathogenesis of inflammatory reactions like rheumatoid disease ...

Vunakizumab, an interleukin-17 inhibitor, shows improved efficacy over placebo in treating active psoriatic arthritis at week ...

The following represents disclosure information provided by authors of this manuscript. All relationships are considered compensated. Relationships are self-held unless noted. I = Immediate Family ...

Interleukins (ILs), a group of cytokines, are produced by leukocytes and non-immune cells like endothelial, fibroblasts, smooth muscle, epithelial and bone marrow cells. 1 ILs mainly act as ...

Researchers have identified a novel strategy to reduce immune-related adverse events from immunotherapy treatment by targeting the cytokine interleukin-6 (IL-6). Researchers at The University of Texas ...

Adjuvant High-Dose Bolus Interleukin-2 for Patients With High-Risk Renal Cell Carcinoma: A Cytokine Working Group Randomized Trial Purpose: This three-arm randomized study compares response rates and ...

Interleukin-6 (IL-6) is a pleiotropic cytokine that may play a role in the regulation of various aspects of the immune response, inflammation, hematopoiesis, and bone metabolism. IL-6 acts by binding ...