DJ-1 is a protein with wide subcellular distribution and pleiotropic functions. The loss-of-function mutations of DJ-1 are associated with autosomal recessive early-onset Parkinson's disease yet the ...

Calcium (Ca2+) drives many cellular functions, though the way it controls quality of proteins in the endoplasmic reticulum ...

Atherosclerosis and related cardiovascular diseases represent one of the greatest threats to human health worldwide. Despite important progress in prevention and treatment, these conditions still ...

Alexander Chernorudskiy, Ersilia Varone, Sara Francesca Colombo, Stefano Fumagalli, Alfredo Cagnotto, Angela Cattaneo, Mickael Briens, Mireille Baltzinger, Lauriane ...

The endoplasmic reticulum plays a more important role in type 2 diabetes and its complications than previously believed, new research suggests. To make their discovery, scientists identified several ...

Established in 1926, Plant Physiology is an international journal devoted to physiology, biochemistry, cellular and molecular biology, genetics, biophysics, and environmental biology of plants. Plant ...

Inside cells, there exists an extensive system of canals known as the endoplasmic reticulum (ER), which consists of membrane-encased tubes that are partially broken down as needed -- for instance in ...

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Increased lipid content in the steatotic liver induces chronic endoplasmic reticulum (ER) stress, mainly via the alteration of Ca 2+ homeostasis Classic ER stress responses such as ER-associated ...